Scientists have discovered that a specific part of the COVID-19 virus, called the S2' helix, is more resistant to antibodies designed to fight it than another similar part, the stem helix. This means that even if the virus mutates and becomes less recognizable to these antibodies, the S2' helix will be harder for them to target. Researchers tested various mutations in both parts of the virus and found that only a few minor changes in the S2' helix reduced its ability to be neutralized by antibodies, while many more significant changes occurred in the stem helix. This suggests that targeting the S2' helix could lead to the development of more effective and long-lasting COVID-19 treatments with fewer chances of the virus becoming resistant.