Nigeria's anti-malarial drug policies have shown varying levels of effectiveness and cost-efficiency across different presidential regimes. Since 1999, the government has implemented different policies, with varying levels of investment and results. The study found that the most effective policy was implemented from 1999 to 2007, which reduced malaria prevalence by 35% and saved lives, but at a cost of about $500,000 per life saved. In contrast, policies implemented in the 2007-2010 and 2010-2015 periods were less effective and more expensive, with lower savings per life saved. Overall, the study suggests that investing in anti-malarial drug policies can be a cost-effective way to reduce the burden of malaria in Nigeria.