Researchers have found that people with Alzheimer's disease often have disrupted white matter in their brains, which can be associated with elevated levels of a protein called amyloid-beta and a decline in cognitive function. The study used imaging tests to look at the brain's white matter and found that those with Alzheimer's disease had reduced connectivity between brain regions, which can affect memory and thinking. The study also found that the level of amyloid-beta in the brain was linked to reduced connectivity in the white matter, and that this was more pronounced in women. Overall, the study suggests that disrupted white matter in the brain may be an important factor in the progression of Alzheimer's disease.